بررسی تاثیر پروژسترون بر پراکسیداسیون لیپیدی و اختلال حافظه ناشی از مدل آلزایمر حاصل از تزریق موضعی استرپتوزوتوسین در رت

Introduction: Alzheimer&rsquo;s disease is one of the most prevalent brain neurodegenerative diseases and the most common cognitive deficits are memory dysfunction and spatial perception impairment. Progesterone has a neorostroid action in hippocampal neurogenesis, synaptic stability and spatial learning and memory and has antioxidant effect. Since oxidative stress is involved in the pathogenesis of Alzheimer's disease, and conflicting results were reported about the effects of progesterone on therefore in Alzheimer&rsquo;s, the present study investigated the effect of microinjection of three doses of progesterone on the process of spatial memory and lipid peroxidation and total peroxidation in the hippocampus in the experimental model of AD. Methods: 42 adult male Wistar rats weighting 250&plusmn;50 g were randomly divided into six main groups (n=7): control group, sham group, Alzheimer&rsquo;s model (intracerebroventricular injection of streptozotocin), Alzheimer model + progesterone (0.5, 1.5, 2&micro;g/kg). 2 weeks after injection of streptozotocin (3 mg/kg), Alzheimer's was induced then progesterone injected in different doses. After termination of behavioral testing days, the hippocampus was removed to measure the levels of oxidative stress parameter to measure levels of oxidative stress parameters. Statistical analysis was performed using analysis of variance (ANOVA). Results: Results showed that intraventricular injection of STZ decreased spatial memory in comparison to control group (P<0.001). Administration progesterone significantly improved spatial memory in experimental models of Alzheimer's rats (P<0.001). MDA and SOD in all doses of progesterone showed a significant reduction compared to the AD animals (P<0.001). Conclusion: Progesterone can prevent a decrease in spatial learning and memory by reducing oxidative stress in the hippocampus of rats with Alzheimer's.